Panama neither bans crypto nor licenses it, and the two facts sit together. The Superintendencia del Mercado de Valores stated in Opinión 04-2025 of 27 August 2025 that cryptocurrencies such as ether and bitcoin are not among the products of the activities it supervises - investing for client account in securities, financial instruments and currencies - so regulating, supervising or overseeing crypto-related activity falls outside its competence, and a business built on custody and facilitation of crypto exchange needs no licence, registration or special authorisation from it.
The contract itself does not change by geography: a ZRO perpetual settles in USDC everywhere.
9 venues open LayerZero perps to traders in Panama.
ApeX
Aster
Avantis
gTrade
Helix
Hyperliquid
Lighter
PacificaFour steps from sign-up to an open position.
The Dirección General de Ingresos states the general territorial principle: income tax is owed by whoever receives income from activities carried out in Panamanian territory, irrespective of nationality, domicile or residence, and the annual return covers income and the expenses originated or caused in Panama that produced the taxed profit.
Trading LayerZero from Panama: legal.
Superintendencia del Mercado de Valores (SMV, securities), Superintendencia de Bancos de Panamá (SBP, banking) and Dirección General de Ingresos (DGI, taxation); none supervises virtual assets, since no legal framework exists.
For LayerZero traders in Panama: Panama's Central Bank expects any licensed crypto financial institution to implement strong anti-money-laundering and KYC controls, including full due diligence on customers.
Panama traders can fund LayerZero positions using USDT P2P (PAB) and Yappy.